Clinical cases of adult patients with malocclusions associated with underlying skeletal discrepancies are presented. Treatment was carried out according to the diagnostic and biomechanical principles of Professor Sato’s technique. The therapeutic approach involves the use of MEAWs (Multiloop Edgewise Archwires), characterized by multiple loops that allow three-dimensional control of tooth movement, the vertical dimension, and the occlusal plane. Diagnostic assessment is based on cephalometric and functional evaluations aimed at identifying the etiopathogenetic mechanisms underlying the malocclusion, with particular attention to mandibular position, occlusal plane inclination, and posterior interferences. An individualized treatment plan is then developed on the basis of these findings. Through the selective use of MEAWs combined with intermaxillary elastics, controlled changes in the occlusal plane can be achieved, promoting mandibular repositioning and improving sagittal and vertical relationships. This technique therefore makes it possible to manage complex malocclusions associated with significant skeletal discrepancies, while limiting dentoalveolar compensation and pursuing a functional and stable occlusion.